Defensins knowledgebase: a manually curated database and information source focused on the defensins family of antimicrobial peptides

نویسندگان

  • Shalin Seebah
  • Anita Suresh
  • Shaowei Zhuo
  • Yong How Choong
  • Hazel Chua
  • Danny Chuon
  • Roger Beuerman
  • Chandra Verma
چکیده

The defensins knowledgebase is a manually curated database and information source focused on the defensin family of antimicrobial peptides. The current version of the database holds a comprehensive collection of over 350 defensin records each containing sequence, structure and activity information. A web-based interface provides access to the information and allows for text-based searching on the data fields. In addition, the website presents information on patents, grants, research laboratories and scientists, clinical studies and commercial entities pertaining to defensins. With the rapidly increasing interest in defensins, we hope that the knowledgebase will prove to be a valuable resource in the field of antimicrobial peptide research. The defensins knowledgebase is available at http://defensins.bii.a-star.edu.sg/.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

PhytAMP: a database dedicated to antimicrobial plant peptides

Plants produce small cysteine-rich antimicrobial peptides as an innate defense against pathogens. Based on amino acid sequence homology, these peptides were classified mostly as alpha-defensins, thionins, lipid transfer proteins, cyclotides, snakins and hevein-like. Although many antimicrobial plant peptides are now well characterized, much information is still missing or is unavailable to pote...

متن کامل

Basic insight on plant defensins

Defensins are small cysteine-rich peptides with antimicrobial activity. Plant defensins have a characteristic threedimensional folding pattern that is stabilized by eight disulfide-linked cysteines. This pattern is very similar to defense peptides of mammals and insects, suggesting an ancient and conserved origin. Functionally, these proteins exhibit a diverse array of biological activities, al...

متن کامل

Expression and polymorphism of defensins in farm animals.

Due to their activity against bacteria, viruses, and fungi, antimicrobial peptides are important factors in the innate resistance system of humans and animals. They are called "new generation antibiotics" for their potential use in preventive and therapeutic medicine. The most numerous group of antimicrobial peptides is a family of cationic peptides which include defensins and cathelicidins. Am...

متن کامل

θ-Defensins: Cyclic Antimicrobial Peptides Produced by Binary Ligation of Truncated α-Defensins

The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus θ-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized αand β-defensin families, possesses broad spectrum microbicidal activities against bacteria, fungi, and protects mo...

متن کامل

Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.

Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents. Antimicrobial peptides appear to be key components of innate defences against bacteria, viruses, and fungi. Among the others, defensins possess a strong microbicidial activity. Defensins are cationic and amphipathi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 35  شماره 

صفحات  -

تاریخ انتشار 2007